Ovarian cancer

Of all gynecologic malignancies, ovarian genus Cancer continues to concord the highest death rate rate and is the most difficult to diagnose. In the United States female person population, ovarian bungholecer ranks fifth in absolute mortality rate among crabmeat related deaths (13,000/yr). In most reported cases, ovarian cancer, when first diagnosed is in stages 3 or IV in about 60 to 70% of patients which further complicates treatment of the indisposition (Barber, 3). Early detection in ovarian cancer is hampered by the lack of appropriate neoplasm markers and clinically, most patients fail to grow significant symptoms until they reach advanced stage disease. The characteristics of ovarian cancer have been studied in primary tumors and in conventional ovarian tumor cellular telephone lines which provide a reproducible source of tumor material. Among the major clinical problems of ovarian cancer, malignant progression, rapid emergence of drug resistance, and associa ted cross-resistance remain unresolved. ovarian cancer has a high frequency of metastasis yet mainly remains situate within the peritoneal cavity. Tumor teaching has been associated with aberrant, dysfunctional view and/or mutation of various genes. This can include oncogene overexpression, increase or mutation, aberrant tumor suppressor expression or mutation. Also, subversion of forces antitumor resistant responses may play a contribution in the pathogenesis of cancer (Sharp, 77). Ovarian clear cell glandular carcinoma was first lay out forth by Peham in 1899 as hypernephroma of the ovary because of its resemblance to renal cell carcinoma. By 1939, Schiller state a histologic parity to mesonephric tubules and classified these tumors as mesonephromas. In 1944, Saphir and Lackner described two cases of hypernephroid carcinoma of the ovary and proposed clear cell glandular carcinoma as an alternative term. Clear cell tumors of the ovary are instantly generally c onsidered to be of mullerian and in the geni! tal tract of mullerian origin. A number of examples of clear cell adenocarcinoma have been... If you requirement to get a full essay, array it on our website: OrderCustomPaper.com

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